產(chǎn)品目錄

規(guī)格	10mg 25mg 100mg
CAS	62669-70-9
別名	R-22420,R-302,RH123
化學(xué)名	3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-xanthylium, monochloride
分子式	C21H17N2O3 Cl
分子量	380.8
溶解度	≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide;10mg/ml in HCl(0.1M)
儲存條件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Rhodamine 123 is a fluorescent tracer dye used as substrate for P-glycoprotein.

Fluorescent tracer dyes represent a class of sub-cellular probes allowing the examination of cellular processes in real-time with minimal impact upon such processes. These tracer dyes are becoming increasingly used for the examination of membrane transport processes, since they are easy-to-use and cost effective probes for a number of membrane protein transporters, such as P-glycoprotein.

In vitro: Rhodamine 123, which was identified as a member of the rhodamine family of flurone dyes, was used to examine membrane transport by the ABCB1 gene product, MDR1. Previous study determined the λmax for excitation and emission for rhodamine 123 in commonly used solvents and extraction buffers, indicating that the fluorescence of rhodamine 123 was highly dependent on the chemical environment. The optimal parameters are 1% methanol in HBSS. In addition, the uptake of rhodamine 123 into cells was via both passive and active processes, and this occurred mainly by OATP1A2-mediated transport. Furthermore, this previous study quantified the intracellular sequestration and metabolism of rhodamine 123, showing that these were both cell line-dependent factors that might influence the interpretation of transport assays [1].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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