產(chǎn)品目錄

規(guī)格	5mg 10mg 25mg 50mg
CAS	153322-05-5
別名	AZD 6765,AR-R 15896AR
化學名	(αS)-phenyl-2-pyridineethanamine
分子式	C13H14N2
分子量	198.3
溶解度	≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

IC50: 4-7 μM

Lanicemine is a NMDA channel blocker.

NMDA receptors, glutamate-gated cation channels with high calcium permeability, play critical roles in various aspects of the biology. They are important for the development of the CNS, generation of rhythms, and the processes underlying memory, learning, and neuroplasticity.

In vitro: Previous study with lanicemine and ketamine found that both compounds could bind with low-to-moderate affinity to sites within the NMDA channel pore, exhibit strong voltage dependence, and have similar lack of NR2A vs NR2B subunit selectivity [1].

In vivo: In animal study, cortical EEG recordings were obtained from rats trained to perform an auditory detection task for food reward. Results showed that both lanicemine and ketamine produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for ketamine were tightly coupled to increases in locomotor activity, indicating that lanicemine not only engaged brain circuits involved in the generation of gamma-EEG, but also influenced these networks independent of the broader systemslevel disruptions typical of ketamine [1].

Clinical trial: A qEEG crossover study was conducted in healthy volunteers but was stopped earlier than planned following two serious adverse events occurring during ketamine infusion. Significant increases in gamma-band EEG were found for both lanicemine and ketamine, and baseline-corrected gamma-EEG following lanicemine treatment was statistically indistinguishable from ketamine. Moreover, both lanicemine and ketamine produced significant reductions in prefrontal theta-cordance. Furthermore, no serious adverse events were observed associated with lanicemine [1].

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原創(chuàng)作者：上海莼試生物技術有限公司

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