產(chǎn)品目錄

規(guī)格	1 g 5 g 10 g 25 g
CAS	5/5/2113
別名	N/A
化學名	N/A
分子式	C8H10ClN5·HCl
分子量	248.1
溶解度	DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 5 mg/ml
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

1-(3-Chlorophenyl)biguanide (m-CPBG) is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.1 It selectively binds 5-HT3 over 5-HT1A and 5-HT2 receptors (Kis = 0.002, 10, and 10 µM, respectively) but also binds to high and low affinity sites on the dopamine transporter (DAT; IC50s = 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).2,3 m-CPBG induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 µM, respectively).1,4 It induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).1

1.Kilpatrick, G.J., Butler, A., Burridge, J., et al.1-(m-chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonistEur. J. Pharmacol.182(1)193-197(1990) 2.Campbell, A.D., Womer, D.E., and Simon, J.R.The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomesEur. J. Pharmacol.290(2)157-162(1995) 3.Higgins, G.A., Joharchi, N., and Sellers, E.M.Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in ratsJ. Pharmacol. Exp. Ther.264(3)1440-1449(1993) 4.Edwards, E., Hampton, E., Ashby, C.R., et al.5-HT3-like receptors in the rat medial prefrontal cortex: Further pharmacological characterizationBrain Res.733(1)21-30(1996)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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