產(chǎn)品目錄

規(guī)格	1 mg
CAS	53648-55-8
別名	N/A
化學名	N/A
分子式	C16H23NO
分子量	245.4
溶解度	DMSO: slightly soluble,Methanol: slightly soluble
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Dezocine is a partial agonist of the µ- and κ-opioid receptors.1 It is selective for µ- and κ-opioid receptors (Kis = 1.46 and 22.01 nM, respectively) over the δ-opioid receptor (Ki = 398.6 nM). Dezocine inhibits the norepinephrine transporter (NET) and serotonin transporter (SERT) with Ki values of 0.001 and 109 nM, respectively.2 It stimulates [35S]GTPγS binding to CHO membranes expressing the human µ- and κ-opioid receptors with Emax values of 45.8 and 33.6% compared to the µ- and κ-agonists DAMGO and U50,488 H, respectively, when used at a concentration of 10 µM.1 It has antinociceptive effects in mice in the acetic acid abdominal constriction test (ED50 = 0.02 mg/kg) and the formalin test (ED50s = 0.4 mg/kg for both phases).1 Dezocine (10 mg/kg) increases the latency to tail withdrawal in the tail-flick test in rats.3 It also decreases the number of lung metastases in a 4T1 murine mammary cancer model when administered at doses ranging from 0.75 to 2 mg/kg.4 Formulations containing dezocine have been used in the treatment of post-operative pain.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術有限公司

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