產(chǎn)品目錄

規(guī)格	500 μg 1 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C19H16D4N2O3
分子量	328.4
溶解度	Acetone: soluble,Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Dolasetron-d4 is intended for use as an internal standard for the quantification of dolasetron by GC- or LC-MS. Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 20 nM).1 It is selective for 5-HT3 receptors over 5-HT1A, 5-HT1B, 5-HT2, dopamine D2, α1-, α2-, and β-adrenergic, M1-5 muscarinic acetylcholine, and neurokinin-1 (NK1) receptors (IC50s = >10 μM for all).2 Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC50 = 3.8 nM).1 It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin in ferrets when administered at doses of 0.5 or 2 mg/kg.2 Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

1.Beoijinga, P.H., Galvan, M., Baron, B.M., et al.Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cellsEur. J. Pharmacol.219(1)9-13(1992) 2.Miller, R.C., Galvan, M., Gittos, M.W., et al.Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptorsDrug Develop. Res.28(1)87-93(1993)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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