產(chǎn)品目錄

規(guī)格	5mg 10mM*1mL in Water 50mg 100mg 200mg 500mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C15H19ClN2
分子量	262.78
溶解度	H2O: ≥ 30 mg/mL (114.16 mM)
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

ML204 hydrochloride is a novel, potent, selective TRPC4 channel inhibitor with IC50 of 0.96 uM. exhibit 19-fold selectivity against TRPC6 channels in similar fluorescent assays.target: ML204IC50: 0.96 uMIn vitro: ML204 inhibited TRPC4β-mediated intracellular Ca2+ rise.ML204 at 10 μm showed >50% inhibition in only 7 of 68 binding assays for 68 GPCRs, ion channels, and transporters.[1] ML204 afforded good selectivity (19-fold) against TRPC6 channels and more modest selectivity against TRPC3 and TRPC5 (9-fold) channels. [2]In vivo: The selectivity of ML204 show no appreciable block by 10-20 μm ML204 of TRPV1, TRPV3, TRPA1, and TRPM8, as well as KCNQ2 and native voltage-gated sodium, potassium, and calcium channels in mouse dorsal root ganglion neurons.[1]

[1]. Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. [2]. Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program.

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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