產(chǎn)品目錄

規(guī)格	2mg 5mg 10mg 50mg 100mg
CAS	1448671-31-5
別名	N/A
化學(xué)名	5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
分子式	C21H24F3N5O5S
分子量	515.5
溶解度	≥ 51.6mg/mL in EtOH, ≥ 51.5mg/mL in DMSO
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Ki = 1.6 nM for MCT1

AZD 3965 is a potent inhibitor of monocarboxylate transporter 1 (MCT1).

Inhibition of monocarboxylate transporter 1 (MCT1) is currently considered as a promosing therapeutic way to block lactate shuttling in tumor cells lacking monocarboxylate transporter 4.

In vitro: Previous study found that the in-vitro AZD3965 sensitivity varied and was highest in hypoxia. To further support that AZD3965 targeted MCT1, NCIH1048 cells were engineered to inducibly overexpress MCT1. It was found that when MCT1 was overexpressed, the EC50 of AZD 3965 against NCI-H1048 was increased from 0.14 to 10.5 nM, which was consistent with AZD3965 acting through MCT1 inhibition [1].

In vivo: COR-L103 xenograft studies were conducted to test whether the in-vitro effect of AZD3965 could be recapitulated in vivo. COR-L103 tumor-bearing mice were treated with AZD3965 at 100 mg/kg BID for 21 days. The pharmacokinetic analyses showed that AZD3965 at 100 mg/kg BID led to free concentrations of AZD3965 predicted to inhibit lactate transport. Moreover, AZD3965 treatment was able to reduce the growth of CORL103 tumors significantly, though tumor regression was not observed, which was consistent with AZD3965 only targeting the hypoxic fraction of the tumor [1].

Clinical trial: A phase I trial of AZD3965 in patients with advanced cancer is currently recruiting participants [2].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

在線(xiàn)咨詢(xún)

留言注意事項(xiàng)：

1.遵守中華人民共和國(guó)有關(guān)法律、法規(guī)，尊重網(wǎng)上道德，承擔(dān)一切因您的行為而直接或間接引起的法律責(zé)任。

2.請(qǐng)您真實(shí)的反映產(chǎn)品的情況,不要捏造、誣蔑、造謠。如對(duì)產(chǎn)品有任何疑問(wèn),也可以留言咨詢(xún)。

3.未經(jīng)本站同意，任何人不得利用本留言簿發(fā)布個(gè)人或團(tuán)體的具有廣告性質(zhì)的信息或類(lèi)似言論。

您感興趣的產(chǎn)品*
您的單位*
聯(lián)系人*
聯(lián)系電話(huà)*
詳細(xì)地址*
常用郵箱*
請(qǐng)輸入您對(duì)我們的意見(jiàn)或建議*
驗(yàn)證碼*

同類(lèi)產(chǎn)品

WOBE437 Tiagabine Tiagabine hydrochloride Rhod-FF AM Rhod-2 (potassium salt) Rhod-2 (sodium salt) Rhod-5N AM Rhod-FF (potassium salt) Quin-2 (potassium salt) Vigabatrin

訂購(gòu)流程

訂貨流程

產(chǎn)品訂購(gòu)說(shuō)明:

1、報(bào)價(jià)含普票、運(yùn)費(fèi)。

2、常用試劑備貨充足，除對(duì)溫度要求極其嚴(yán)格的產(chǎn)品當(dāng)天可發(fā)貨。

3、進(jìn)口原裝產(chǎn)品要3-6周的貨期，詳細(xì)情況請(qǐng)咨詢(xún)客服。

4、訂貨時(shí)間為工作日每周一至周五16:00之前。

5、如需代為檢測(cè)，標(biāo)本對(duì)環(huán)境溫度高，可聯(lián)系客服安排專(zhuān)人取樣（限省內(nèi)客戶(hù)）。

6、代測(cè)免收代測(cè)費(fèi)，一周出結(jié)果。

7、產(chǎn)品因運(yùn)輸途中包裝破損請(qǐng)拒絕簽收，做退回。我們將在24小時(shí)之內(nèi)為您補(bǔ)發(fā) 損壞產(chǎn)品。

8、如因單位財(cái)務(wù)制度原因，可申請(qǐng)先發(fā)貨，報(bào)賬后付款（此條款僅限醫(yī)院、學(xué)校信譽(yù)良好客戶(hù)）。

付款方式

普票匯款信息

賬戶(hù) 名：上海生物

開(kāi) 戶(hù) 行：中國(guó)銀行山東省分行營(yíng)業(yè)部

賬號(hào)：2169 2341 6278

為方便廣大客戶(hù)辦理貨款我公司提供多個(gè)銀行的賬戶(hù)，學(xué)校、醫(yī)院客戶(hù)購(gòu)買(mǎi)產(chǎn)品如因單位財(cái)務(wù)制度原因可先發(fā)貨待報(bào)賬后匯款，請(qǐng)及時(shí)告知銷(xiāo)售人員已做具體操作。