產(chǎn)品目錄

規(guī)格	10mg 50mg
CAS	389888-02-2
別名
化學名	(S)-2-amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)propanoic acid
分子式	C10H13N3O4
分子量	239.23
溶解度	<11.96mg/ml in H2O
儲存條件	Desiccate at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

(S)-CPW 399 is a potent and selective agonist of AMPA receptor with Ki value of 747 nM [1].

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) is an ionotropic transmembrane receptor for glutamate and mediates fast synaptic transmission in the central nervous system. AMPA receptors are oligomeric assemblies of four protein subunits, GluR1-4.

(S)-CPW 399 is a potent and selective AMPA receptor agonist. (S)-CPW 399 exhibited affinity with Ki values of 109, 218, 2137 and 1756 nM for GluR1, GluR2, GluR3 and GluR4 receptors, respectively [1]. In mouse cerebellar granule cells, (S)-CPW 399 induced neuronal cell death in a concentration- and time-dependent way with EC50 value of 70 μM and increased intracellular free-calcium levels ([Ca2+]i ) in a concentration-dependent way with EC50 value of 5 μM [2]. In rat cerebellar granule cells, CPW-399 increased the expression of GABAA receptor δ subunit, which relied on NMDA receptor activation [3]. In Sf9 cells expressing iGluR5, (S)-CPW 399 exhibited affinity for iGluR5 with Ki value of 44 nM. In Xenopus læVis Oocytes, (S)-CPW 399 exhibited agonist activity with EC50 values of 24.9, 13.9, 224 and 34.3 μM for iGluR1, iGluR2, iGluR3 and iGluR4 receptors, respectively [4].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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