產(chǎn)品目錄

規(guī)格	20mg
CAS	482-44-0
別名	Ammidin, 8-Isopentenyloxypsoralen; 9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one
化學(xué)名	9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one
分子式	C16H14O4
分子量	270.28
溶解度	DMF: 30 mg/mL,DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL,DMSO: 20 mg/mL,Ethanol: 10 mg/mL
儲(chǔ)存條件
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Imperatorin is reported as an anti-cancer medicine with many targets to induce cell apoptosis, such as enhancing p53 expression [1], inducing Mcl-1 degradation [2], activating activation of caspase-3, caspase-8, caspase-9 [3].

When tested with human cancer cell lines (SNU 449-liver cancer and HCT-15-colon cancer), imperatorin treatment promoted cell apoptosi in a dose-dependent manner via modulating expression of apotosis-related proteins [4]. In human embryonic kidney cells, imperatorin treatment significantly attenuated H2O2-induced ROS production [5]. When tested with human hepatoma HepG2 cells, administration of imperatorin inhibited cell proliferation in a time- and dose- dependent manner [3]. In human lung cancer H23 cells, imperatorin was shown to enhance the expression of p53 and induced cells apoptosis at sub-toxic concentrations [1].

In nude mouse model bearing HepG2 cells, treatment with imperatorin significantly suppressed tumor growth in a dose-dependent manner [3].

It is also reported that imperatorin inhibits voltage-gated K+ channels and ATP-sensitive K+ channels when tested with neuronal NG-108-15 cells [6].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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