產(chǎn)品目錄

規(guī)格	10mM (in 1mL DMSO) 5mg 10mg 50mg
CAS	125316-60-1
別名	CD437
化學(xué)名	6-(3-((1s,3R,5S,7s)-adamantan-1-yl)-4-hydroxyphenyl)-2-naphthoic acid
分子式	C27H26O3
分子量	398.5
溶解度	DMF: 10 mg/ml,DMSO: 16 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.05 mg/ml,Ethanol: 1 mg/ml
儲存條件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

CD 437 is a selective agonist of RARγ [1].

Retinoic acid receptor gamma (RAR-γ) is a nuclear receptor that is activated by 9-cis retinoic acid and all-trans retinoic acid. RAR-γ also functions as a transcription factor.

CD 437 is a selective RARγ agonist. In tumor cells, CD437 induced RAR-γ-dependent differentiation and apoptosis. Also, CD437 induced DNA adduct formation and p53-independent DNA damage response [1]. In DU145 human prostate cancer cells, CD437 rapidly reduced IκBα and increased nuclear translocation of the NF-κB subunit p65. Also, CD437 increased the DNA-binding activity of NF-κB and induced DR4 expression and apoptosis [2]. In human melanoma A375 cells, CD437 induced apoptosis, which was mediated by the activation of NF-κB and RIG-I (retinoic acid inducible gene I) pathway [3]. In human osteosarcoma cells, CD437 activated c-Jun N-terminal kinase 1 (JNK1) through the upregulation of thioredoxin-binding protein 2 (TBP2) and induced apoptosis. Also, CD437 induced TBP2 mRNA expression by recruitment of ETS1 transcription factor [4].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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