產(chǎn)品目錄

規(guī)格	10mg 50mg
CAS	Cas No.
別名
化學(xué)名	N-(5-(1H-imidazol-2-yl)-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide dihydrochloride
分子式	C23H20N4O2.2HCl
分子量	457.35
溶解度	Soluble in DMSO
儲(chǔ)存條件	Desiccate at RT
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

AZ 12080282 dihydrochloride is a selective inhibitor of Hh with IC50 value <0.012 μM [1]. It is also reported that AZ 12080282 also has a selective inhibition to p38α with low nanomolar potency [1].

Hedgehog (Hh) signaling plays an important role in a wide variety of developmental processes, including larval body segment development and adult appendages formation. Abnormal activation of Hh pathway may lead to developmental disease by transforming adult stem cells into cancer stem cells and also leads to cancers via increasing in Angiogenic Factors, Cyclins, anti-apoptotic genes and decreasing in apoptotic genes [2].

AZ 12080282 is a potent Hh inhibitor and is different from the other reported Hh inhibitors. When tested with Gli transcription factor reporter cell, AZ 12080282 treatment resulted in the Hh signaling pathway inhibition by using shh stimulated cell differentiation assay [1].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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