產品目錄

規(guī)格	50g 100g 250g
CAS	150-86-7
別名	trans-Phytol
化學名	3,7R,11R,15-tetramethyl-2E-hexadecen-1-ol
分子式	C20H40O
分子量	296.5
溶解度	≤10mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產品描述：

Phytol is an activator of retinoid X receptors (RXRs) [1,2].

The retinoid X receptors (RXRs) are nuclear receptors activated by 9-cis retinoic acid. RXRs are members of the steroid/thyroid hormone receptor superfamily of DNA binding nuclear hormone receptors. The RXRs are cofactors required for transcription activated by some other members of the steroid/thyroid hormone receptor superfamily, including the all-truns retinoic acid, vitamin D, thyroid hormone, and peroxisome proliferator-activated receptors. Some RXR null mutations in mice show phenotypic effects similar to vitamin A deficiency. Retinoids, metabolites of vitamin A, act as signalling molecules in embryogenesis and as stimulators of cellular differentiation. The retinoids has been successfully used in treating skin diseases and some forms of cancer [3].

Phytol activated retinoid X receptors (RXRs) with the Ki range from 2.3 to 67.2 μM [2]. Phytol was a diterpene alcohol obtained from the degradation of chlorophyll. Phytol has been used in the synthesis of Vitamins E and K. During the digestion process of ruminants, phytol converted to phytanic acid [2]. Phytol was readily absorbed in the small intestine and converted to phytanic acid in human. In a number of metabolic disorders, Phytanic acid accumulated to toxic levels[2]. The conversion of phytol to phytanic acid was regulated via the activation of peroxisome proliferator-activated receptor α (PPARα). Phytol showed sedative and anxiolytic effects through interaction with the GABAA receptor, and it was explored as an antischistosomal agent in a mouse model of schistosomiasis [4].

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原創(chuàng)作者：上海莼試生物技術有限公司