產(chǎn)品目錄

規(guī)格	5mg 10mg 50mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C43H56F3N7O11
分子量	903.94
溶解度	N/A
儲存條件	N/A
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].

β-Casomorphin, bovine TFA (0.1μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2].β-Casomorphin, bovine TFA (0.1μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2].β-Casomorphin, bovine TFA does not modify the expression of rMuc1, rMuc4, and rMuc5AC[2].β-Casomorphin, bovine TFA (0.1μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].

β-Casomorphin, bovine TFA (7.5×10-6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].β-Casomorphin, bovine TFA (7.5×10-6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].β-Casomorphin, bovine TFA (7.5×10-6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].β-Casomorphin, bovine TFA (7.5×10-6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3]. Animal Model: Male Sprague-Dawley (SD) rats (200 g±10 g)[3]

[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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