產(chǎn)品目錄

規(guī)格	1 mg 5 mg
CAS	1189455-63-7
別名	N/A
化學(xué)名	N/A
分子式	C18H10ClD8N3O
分子量	335.9
溶解度	Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Loxapine-d8 is intended for use as an internal standard for the quantification of loxapine by GC- or LC-MS. Loxapine is an atypical antipsychotic.1 It binds to the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 2,456, 7.7, 9.5, 32, and 87.2 nM, respectively), as well as dopamine D2, histamine H1, and M3 muscarinic acetylcholine receptors (Kis = 12, 7, and 122 nM, respectively). Loxapine also binds to α1A-, α2A-, α2B-, and α2C-adrenergic receptors (Kis = 31, 150.8, 107.6, and 79.9 nM, respectively). Formulations containing loxapine have been used in the treatment of schizophrenia.

1.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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