• 13585831301
  • 021-59541103 021-60443211
  • 3004967995

Itopride hydrochloride

  • 產(chǎn)品貨號(hào):CS-01Y76635
  • 產(chǎn)品價(jià)格:電議
  • 產(chǎn)品產(chǎn)地:進(jìn)口、國(guó)產(chǎn)
  • 包裝類(lèi)型:100mg 500mg
  • 采購(gòu)熱度:187
  • 庫(kù)存:100
  • CAS號(hào):122892-31-3
  • 方法:
  • 含量:>99.50%
  • 品牌名稱(chēng):莼試
  • 分子式:C20H27ClN2O4
  • 分子量:394.89

簡(jiǎn)介內(nèi)容:質(zhì)量保證、價(jià)格優(yōu)惠

在線訂購(gòu)  免費(fèi)訂購(gòu)熱線:021-59541103 021-60443211

標(biāo)簽:Itopride hydrochloride 

產(chǎn)品目錄

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聯(lián)系人:高小姐

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商品詳情購(gòu)物流程代測(cè)服務(wù)付款方式常見(jiàn)問(wèn)題

化學(xué)性質(zhì):                                                                                                             

規(guī)格

100mg 500mg

CAS

122892-31-3

別名

 

化學(xué)名

N-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxybenzamide hydrochloride

分子式

C20H27ClN2O4

分子量

394.89

溶解度

DMF: 1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml

儲(chǔ)存條件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

產(chǎn)品描述:                                                                                                            

IC50: 2.04 μM

Itopride is an acetylcholinesterase (AchE) inhibitor.

Acetylcholinesterase plays key roles in the termination of impulse transmission by rapidly hydrolyzing the neurotransmitter acetylcholine in varioius cholinergic pathways in both central and peripheral nervous systems.

In vitro: Itopride was found to inhibit both AChE and horse serum butyrylcholinesterase (BuChE). The itopride IC50 against AChE was, however, 100-fold less than that against BuChE. The recovery of AChE activity inhibited by low dose of neostigmine was partial, but that inhibited by itopride was complete. Double reciprocal plots showed that both Vmax and Km were affected by itopride, indicating a "mixed" type inhibition, although primarily being an uncompetitive one. In addition, the inhibitory effect of itopride on cholinesterase (ChE) activity in guinea pig gastrointestine was much weaker than that on pure AChE [1].

In vivo: Previoius animal study showed that in conscious dogs with implanted strain gauge force transducers, itopride could stimulate contractile activity in the gastrointestinal tract from stomach to colon. Whereas, mosapride was able to stimulate contractile activity only in the gastric antrum and ileum. Moreover, in rats s andguinea pig, itopride could accelerate colonic luminal transit, however, both mosapride and cisapride failed to enhance colonic transit. Such findings suggested that itopride had a stimulatory action on propelling colonic luminal contents, colonic peristalsis, which was quite different from mosapride and cisapride [2].

Clinical trial: Itopride hydrochloride has been clinically used as a gastroprokinetic agent in several countries including Japan, for the symptomatic treatment of functional dyspepsia [2].

特別提醒:                                                                                                              

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療,食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康,請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者:上海莼試生物技術(shù)有限公司

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賬 戶 名:上海生物

開(kāi) 戶 行:中國(guó)銀行山東省分行營(yíng)業(yè)部

  

賬 號(hào):2169 2341 6278

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