產(chǎn)品目錄

規(guī)格	10 mg 25 mg 50 mg 100 mg
CAS	1094-08-2
別名	N/A
化學(xué)名	N/A
分子式	C19H24N2S.HCl
分子量	348.9
溶解度	DMF: 10mg/mL,DMF:PBS (pH 7.2) (1:5): 0.16mg/mL,DMSO: 5mg/mL,Ethanol: 5mg/mL
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Ethopropazine is a butyrylcholinesterase (BChE) inhibitor (IC50 = 15.14 μM in human erythrocyte lysates).1 It is selective for BChE over acetylcholinesterase (AChE) at 500 μM. Ethopropazine also binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively.2 Ethopropazine (0.232 mg/kg) decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with the adenosine A2A receptor antagonist ZM 241395 .3 It reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation when administered at doses of 20 and 30 mg/kg.4 Formulations containing ethopropazine were previously used in the treatment of Parkinson's disease.

1.Ucar, G., Gokhan, N., Yesilada, A., et al.1-N-Substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazolines: a novel cholinesterase and selective monoamine oxidase B inhibitors for the treatment of Parkinson's and Alzheimer's diseasesNeurosci. Lett.382(3)327-331(2005) 2.Burke, R.E.The relative selectivity of anticholinergic drugs for the M1 and M2 muscarinic receptor subtypesMov. Disord.1(2)135-144(1986) 3.González-Lugo, O.E., Ceballos-Huerta, F., Jiméenez-Capdeville, M.E., et al.Synergism of theophylline and anticholinergics to inhibit haloperidol-induced catalepsy: A potential treatment for extrapyramidal syndromesProg. Neuropsychopharmacol. Biol. Psychiatry34(8)1465-1471(2010) 4.Jevtovic-Todorovic, V., Meyenburg, A.P., Olney, J.W., et al.Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic ratsNeuropharmacology44(6)739-748(2003)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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