產(chǎn)品目錄

規(guī)格	5mg 10mg 25mg 50mg
CAS	87233-62-3
別名	N/A
化學(xué)名	N/A
分子式	C17H26N4O?2C4H4O4
分子量	534.6
溶解度	DMSO: Slightly Soluble,Methanol: Slightly Soluble
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Emedastine is a potent and selective histamine H1 receptor antagonist with 37,744-fold and 9,562-fold selectivity over H2 and H3, respectively (Kis = 1.3, 49,067, and 12,430 nM for H1, H2, and H3, respectively). It is selective for H1 receptors with less than 50% inhibition of α1-, α2-, and β1-adrenergic, dopamine D1 and D2, and serotonin 5-HT1 and 5-HT2 receptors at a concentration of 10 μM. It inhibits histamine-induced phosphoinositide turnover and intracellular calcium mobilization in primary human conjunctival epithelial cells (HCECs; IC50s = 1.6 and 2.9 nM, respectively). Emedastine inhibits histamine-stimulated cytokine secretion by primary HCECs, including IL-6, IL-8, and GM-CSF secretion (IC50s = 2.23, 3.42, and 1.50 nM, respectively). In guinea pigs, ocular application of emedastine 4 hours after histamine challenge inhibits vascular permeability with an ED50 value of 0.019% w/v. Formulations containing emedastine have been used in the treatment of allergic conjunctivitis.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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