產(chǎn)品目錄

規(guī)格	1 mg 5 mg 10 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C24H24N4.2HCl [XH2O]
分子量	441.4
溶解度	DMSO: Soluble,Water: Soluble
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

JP-1302 is an antagonist of α2-adrenergic receptors (α2-ARs) that is selective for α2C-ARs over α2A- and α2B-ARs (Kis = 28, 3,150, and 1,470 nM, respectively).1 It reduces immobility time in the forced swim test in mice when administered at doses of 1, 3, and 10 µmol/kg. JP-1302 (5 mg/kg) reverses phencyclidine-induced decreases in prepulse inhibition of the acoustic startle response in rats. It dose-dependently reduces haloperidol-induced bradykinesia and catalepsy in mice.2 JP-1302 (0.3 mg/kg) also increases systolic blood pressure in rats.3

1.Sallinen, J., HÖglund, I., EngstrÖm, M., et al.Pharmacological characterization and CNS effects of a novel highly selective α2C-adrenoceptor antagonist JP-1302Br. J. Pharmacol.150(4)391-402(2007) 2.Imaki, J., Mae, Y., Shimizu, S., et al.Therapeutic potential of α2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disordersNeurosci. Lett.454(2)143-147(2009) 3.Zefirov, T.L., Khisamieva, L.I., Ziyatdinova, N.I., et al.Effect of selective blockade of α?-adrenoceptor subtypes on cardiovascular system in ratsBull. Exp. Biol. Med.158(4)410-412(2015)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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