產(chǎn)品目錄

規(guī)格	500μg 1mg 5mg 10mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C119H206N32O35.C2HF3O2
分子量	2759.12
溶解度	H2O: 25 mg/mL (9.06 mM)
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Colivelin (TFA) is a neuroprotective peptide and activator of STAT3. STAT3 Amyloid-β

Colivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative[2]. Humanin (HN) and its derivatives, such as Colivelin (TFA), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3[1]. Colivelin (TFA) completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM[2].

Humanin (HN) and its derivatives, such as Colivelin (TFA) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ)[1]. Intracerebroventricular administration of Colivelin (TFA) not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42[2].

[1]. Yamada M, et al. Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology. 2008 Jul;33(8):2020-32. [2]. Chiba T, et al. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J Neurosci. 2005 Nov 2;25(44):10252-61.

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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