產(chǎn)品目錄

規(guī)格	500 μg 1 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C71H110N24O18S.XCF3COOH
分子量	1619.9
溶解度	Water: 1 mg/ml
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Bombesin is a neuropeptide with diverse biological activities originally isolated from the skin of B. bombina and B. variegata variegata amphibians.1,2 It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM) and to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM).3 Hypothalamic paraventricular microinfusion of bombesin (100 ng per animal) increases blood glucose, free fatty acids, and corticosterone levels in rats.4 Bombesin (50 ng per animal) injection into the preoptic area decreases food intake by food-deprived or insulin pretreated rats.5 It delays gastric emptying in rats by 55.8% when administered at a dose of 16 μg/kg (i.p.) and inhibits gastric secretion at a dose of 500 ng per animal.6,7

1.Anastasi, A., Erspamer, V., and Bucci, M.Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the European amphibians Bombina and AlytesExperientia27(2)166-167(1971) 2.Weber, H.C.Regulation and signaling of human bombesin receptors and their biological effectsCurr. Opin. Endocrinol. Diabetes Obes.16(1)66-71(2009) 3.Pradhan, T.K., Katsuno, T., Taylor, J.E., et al.Identification of a unique ligand which has high affinity for all four bombesin receptor subtypesEur. J. Pharmacol.343(2-3)275-287(1998) 4.Gunion, M.W., Taché, Y., Rosenthal, M.J., et al.Bombesin microinfusion into the rat hypothalamic paraventricular nucleus increases blood glucose, free fatty acids and corticosteroneBrain Res.478(1)47-58(1989) 5.Babcock, A.M., Barton, C., Gunion, M.W., et al.Bombesin-induced hypothermia and hypophagia are associated with plasma metabolic fuel alterations in the ratPhysiol. Behav.51(5)933-938(1992) 6.Scarpignato, C., and Bertaccini, G.Bombesin delays gastric emptying in the ratDigestion21(2)104-106(1981) 7.Tache, Y., Lesiege, D., and Goto, Y.Neural pathways involved in intracisternal bombesin-induced inhibition of gastric secretion in ratsDig. Dis. Sci.31(4)412-417(1986)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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