產(chǎn)品目錄

規(guī)格	250 mg 500 mg 1 g 5 g
CAS	303-25-3
別名	N/A
化學(xué)名	N/A
分子式	C18H22N2.HCl
分子量	302.8
溶解度	Methanol: 1 mg/ml
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Cyclizine is a histamine H1 receptor antagonist.1,2,3 It binds selectively to histamine H1 receptors (Kd = 5 nM) over H2 and H3 receptors (Kds = 1,600 and >580 nM, respectively).3 Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments with an IC50 value of 5.42 μM but induces histamine release with a 50% release concentration (RC50) of 10.81 μM.4 It reduces LPS-induced nitrite accumulation and protein levels of induced nitric oxide synthase (iNOS) in RAW 264.7 cells when used at a concentration of 100 nM.2 Cyclizine (10 and 20 mg/kg) reduces immobility in the forced swim test in rats.5

1.Hamlin, K.E., Weston, A.W., Fischer, F.E., et al.Histamine antagonists. II.1 Unsymmetrical 1,4-disubstituted piperazinesJ. Am. Chem. Soc.71(8)2731-2734(2019) 2.Králová, J., Raková, L., Pekarová, M., et al.The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicityInt. Immunopharmacol.9(7-8)990-995(2009) 3.Hill, S.J.Distribution, properties, and functional characteristics of three classes of histamine receptorPharmacol. Rev.42(1)45-83(1990) 4.Church, M.K., and Gradidge, C.F.Inhibition of histamine release from human lung in vitro by antihistamines and related drugsBr. J. Pharmacol.69(4)663-667(2019) 5.Khanwelkar, C.C., Gokhale, D.V., Santakke, A.V., et al.Effects of H1-receptor antagonists in antidepressant tests in ratsAl Ameen J. Med. Sci.1(2)84-92(2008)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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