產(chǎn)品目錄

規(guī)格	1 mg 5 mg 10 mg 25 mg
CAS	1401463-54-4
別名	N/A
化學(xué)名	N/A
分子式	C27H35N3O2·2HCl
分子量	506.5
溶解度	DMSO: Soluble,Water: Soluble
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

BAN ORL 24 is an antagonist of the nociceptin (NOP) receptor (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor).1 It is selective for NOP receptors over μ-, δ-, and κ-opioid receptors (Kis = 0.19, 0.34, and >1 μM, respectively). BAN ORL 24 reduces NOP-induced GTPγS binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells. It inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, when used at a concentration of 100 nM. BAN ORL 24 (10 mg/kg) reverses thermal and mechanical antinociceptive activities induced by the dual agonist of μ-opioid and NOP receptors BPR1M97 in mice.2

1.Fischetti, C., Camarda, V., Rizzi, A., et al.Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24Eur. J. Pharmacol.614(1-3)50-57(2009) 2.Chao, P.-K., Chang, H.-F., Chang, W.-T., et al.BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphineNeuropharmacology166107678(2020)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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