產(chǎn)品目錄

規(guī)格	1 mg 5 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C15H5D5O6
分子量	291.3
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 5 mg/ml
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Fisetin-d5 is intended for use as an internal standard for the quantification of fisetin by GC- or LC-MS. Fisetin is a flavonoid that has been found in various fruits and vegetables and has diverse biological activities.1,2,3,4 It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay and inhibits oxidative burst induced by N-Formyl-Met-Leu-Phe in isolated human polymorphonuclear neutrophils (PMNs) when used at a concentration of 10 µM.1,3 Fisetin (10-60 µM) induces cell cycle arrest at the G1 phase and apoptosis in, as well as inhibits the proliferation of, LNCaP prostate cancer cells.2 It inhibits LPS-induced production of nitrite, prostaglandin E2 , and NF-κB activation in RAW 264.7 cells.3 Fisetin (1 mg/animal) reduces tumor growth in a CWR22RΥ1 prostate cancer mouse xenograft model.4

1.Khan, N., Syed, D.N., Ahmad, N., et al.Fisetin: A dietary antioxidant for health promotionAntioxid. Redox Signal.19(2)151-162(2013) 2.Khan, N., Afaq, F., Syed, D.N., et al.Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cellsCarcinogenesis29(5)1049-1056(2008) 3.Wang, L., Tu, Y.-C., Lian, T.-W., et al.Distinctive antioxidant and antiinflammatory effects of flavonolsJ. Agric. Food Chem.54(26)9798-9804(2006) 4.Khan, N., Asim, M., Afaq, F., et al.A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude miceCancer Res.68(20)8555-8563(2008)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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