產(chǎn)品目錄

規(guī)格	5 mg 10 mg 25 mg
CAS	203645-53-8
別名	N/A
化學(xué)名	N/A
分子式	C4HCl2D6O4P
分子量	227
溶解度	Methanol: soluble
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Dichlorvos-d6 is intended for use as an internal standard for the quantification of dichlorvos by GC- or LC-MS. Dichlorvos is an organophosphate insecticide and inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 269 and 44 nM, respectively).1 It also binds to the M2 muscarinic receptor in rat heart homogenates.2 Dichlorvos is lethal to 4-week old German cockroach (B. germanica) nymphs (LD50 = 0.108 μg per insect) and silkworms (B. mori) in third instar (LC50 = 6.63 mg/L) after 24 hours.3,4 It is lethal to zebrafish (D. rerio) embryos (LC50 = 39.75 mg/L after 24 hours) and decreases swimming activity of larvae 6 days after fertilization when administered at a concentration of 25 mg/L in tank water.5 Dichlorvos (150 ppm for 80 weeks) also increases the incidence of benign and malignant neoplasms in male rats from 47 to 88% as compared to controls.6

1.Petroianu, G.A., Schmitt, A., Arafat, K., et al.Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): In vitro effect of tiaprideInt. J. Toxicol.24(2)79-86(2005) 2.Silveira, C.L., Eldefrawi, A.T., and Eldefrawi, M.E.Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterasesToxicol. Appl. Pharmacol.103(3)474-481(1990) 3.Qian, K., Wei, X., Zeng, X., et al.Stage-dependent tolerance of the German cockroach, Blattella germanica for dichlorvos and propoxuJ. Insect Sci.10(1)201(2010) 4.Zhang, Z.-Y., Wang, D.-L., Chi, Z.-J., et al.Acute toxicity of organophosphorus and pyrethroid insecticides to Bombyx moriJ. Econ. Entomol.101(2)360-364(2008) 5.Si man, T.Dichlorvos-induced developmental toxicity in zebrafishToxicol. Ind. Health26(9)567-573(2010) 6.Reuber, M.D.Carcinogenicity of dichlorvosClin. Toxicol.18(1)47-84(1981).

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1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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