產(chǎn)品目錄

規(guī)格	1 mg 5 mg 10 mg
CAS	4431-01-0
別名
化學(xué)名	(3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one
分子式	C12H14O2
分子量	190.23
溶解度	≥ 16.45mg/mL in DMSO
儲(chǔ)存條件	-20°C,
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

IC50: 2.27 and 4.78 μM against L1210 and K562 cell lines

Z-Ligustilide, isolated and purified from the essential oil of A. sinensis. Z-Ligustilide has been reported to facilitate blood circulation and attenuate inflammatory pain behavior.

In vitro: Previous results showed pretreatment with Z-Ligustilide (LIG) improved cell viability significantly. The apoptosis rate in glutamate-induced PC12 cells decreased in the presence of LIG. Western blot results indicated that LIG could decrease the release of Cyt C from mitochondria, up-regulate Bcl-2/Bax ratio and down-regulate Caspase-3 protein expression, resulting in protecting PC12 cells from apoptosis [1].

In vivo: In ovariectomized (OVX) osteopenic rats, the anti-inflammatory potential of LIG was determined by ELISA. LIG was found to be able to inhibit OVX-induced up-regulation of NF-κB activation and the production of TNF-α, iNOS, IL-1β, ICAM-1 and COX-2 significantly. In addition, LIG could suppress MDA and PMN infiltration. The significant anti-inflammatory effect of Z-Ligustilide in experimental OVX osteopenic rats clearly demonstrated that there might be an inflammatory component in the etiology of osteoporosis [2].

Clinical trial: N/A

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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