產(chǎn)品目錄

規(guī)格	5mg 10mg 25mg
CAS	173903-47-4
別名
化學(xué)名	2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide
分子式	C10H7N3O4S
分子量	265.25
溶解度	≥ 26.5mg/mL in DMSO with gentle warming
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

IC50: 0.17 to 0.21 μM for CIVs

Tizoxanide is the active metabolite of nitazoxanide that is a thiazolide anti-infective drug against anaerobic bacteria, protozoa, and a range of viruses.

Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are major public health problems, causing more than an estimated 500 million chronic infections worldwide. Both HBV and HCV are a source of liver disease, and are the major risk factors for hepatocellular carcinoma.

In vitro: Previous study found that tizoxanide showed potent inhibition of both HBV and HCV replication. Tizoxanide also exhibited selective inhibition of intracellular HBV replication and extracellular virus production by 2.2.15 cells. Tizoxanide could selectively reduce intracellular HCV replication in AVA5 cells. Moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (IFNα), or an NS5B (HCV polymerase) inhibitor, 2′-C-methyl cytidine, resulted in synergistic interactions against HCV replication. In addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for AVA5 cells [1].

In vivo: Animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].

Clinical trial: Nitazoxanide, the parent drug of tizoxanide, is currently in phase II clinical development for treating chronic hepatitis C [1].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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