產(chǎn)品目錄

規(guī)格	5mg 25mg
CAS	3922-90-5
別名	4-Methylumbelliferyl α-D-galactoside
化學(xué)名	7-(α-D-galactopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
分子式	C35H61NO12
分子量	687.9
溶解度	DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Oleandomycin is an antibiotic produced by strains of Streptomyces.

In vitro: Oleandomycin has been identified as a macrolide antibiotic demonstrating antimicrobial activity similar to penicillin and erythromycin. In addition, oleandomycin structurally has a macrocyclic lactone ring of 14 carbon atoms with one sugar, oleandrose, and one amino sugar, desoxamine [1].

In vivo: The PK of oleandomycin after i.v. and po administration, both alone and after i.m. pretreatment with metamizole or dexamethasone, was studied in healthy dogs. Results showed that after i.v. injection of oleandomycin alone at 10 mg/kg, the t1/2β, Vd, Cl and AUC were 1.60 h, 1.11 L/kg, 7.36 ml/kg/min and 21.66 μg h/ml, respectively. There were no statistically significant differences following pretreatment with metamizole or dexamethasone. In addition, after po administration of oleandomycin alone, the t1/2β, Cmax, tmax), MAT and Fabs were 1.68 h, 5.34 μg/ml, 1.5 h, 1.34 h and 84.29%, respectively, and the pretreatment with metamizole showed a significantly decreased value for Cmax but the MAT was increased significantly. Statistically significant changes in the PK parameters of oleandomycin following po administration were also seen as a result of pretreatment with dexamethasone. The Cmax was increased and the tmax and MAT were lower [2].

Clinical trial: Up to now, oleandomycin is still in the preclinical development stage.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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