產(chǎn)品目錄

規(guī)格	5mg 25mg
CAS	25999-31-9
別名	Antibiotic X 537A,Ionophore X 537A,X 537A
化學(xué)名	6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methyl-benzoic acid
分子式	C34H54O8
分子量	590.8
溶解度	Soluble in ethanol;methanol;DMSO;dimethyl formamide
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Lasalocid is an ionophore antibiotic.

Lasalocid is produced by Streptomyces lasaliensis and is a mixture of several closely related homologue substances A, B, C, D, E. The sum of the lasalocid homologues B, C, D, E is limited to 10% of the total weight of the active substance, lasalocid.

In vitro: A previous study was conducted to compare effects of the combined use of lasalocid and silybin in chicken hepatoma cells and rat myoblasts cell lines cultures. Results showed that in all performed tests, the lowest lasalocid EC50-values were obtained for chicken hepatocytes. In the rat myoblasts cultures, the lowest lasalocid EC50-values were found. Moreover, a lack of silybin cytotoxic effect was proven for the studied cell lines. An interaction between both substances resulted in a great decrease of lasalocid cytotoxicity. The isobolograms and combination index indicated a significant antagonistic nature of silybin effect in the course of lasalocid cytotoxicity [1].

In vivo: In a animal study, chickens 8 or 9 days old were given a completely purified crystalline amino acid diet. Results showed that the requirement for sulphur-containing amino acids (SAA) was neither increased nor decreased by lasalocid at 125 mg/kg diet. Moreover, lasalocid could cause a significant increase in gain and gain/feed intake when added to diets that were deficient in SAA, but it led to a marked decrease in performance when added to diets adequate in SAA. In addition, at moderate levels of SAA deficiency, lasalocid at 125 mg/kg could neither increase nor decrease the rate and efficiency of weight gain and there was no evidence of the SAA X lasalocid interaction when lasalocid was given in a typical starter diet of maize and soya [2].

Clinical trial: So far, no clinical study has been conducted.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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賬戶(hù) 名：上海生物

開(kāi) 戶(hù) 行：中國(guó)銀行山東省分行營(yíng)業(yè)部

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