產(chǎn)品目錄

規(guī)格	500 μg 1 mg 5 mg
CAS	2061-64-5
別名	N/A
化學(xué)名	N/A
分子式	C28H44O3
分子量	428.7
溶解度	Methanol: soluble
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Ergosterol peroxide is an oxidized sterol and derivative of ergosterol that has been found in S. aspratus and has diverse biological activities.1,2,3,4,5 It is active against the P. falciparum chloroquine-sensitive strain FCA 20/GHA with an IC50 value of 8.2 µM.2 Ergosterol peroxide (6.25-50 µM) induces apoptosis in LNCaP and DU145 prostate cancer cells.3 It inhibits growth of SNU-1 gastric, SNU-354 hepatoma, and SNU-C4 colorectal cancer cells (IC50s = 18.7, 158.2, and 84.6 µM, respectively).6 Ergosterol peroxide (60 µM) inhibits LPS-induced NF-kB DNA-binding activity and production of TNF-α in RAW 264.7 cells.4 Topical application of ergosterol peroxide reduces ear edema in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate with an ID50 value of 0.2 mg/ear.5

1.Nielson, J.R., Fredrickson, E.K., Waller, T.C., et al.Sterol oxidation mediates stress-responsive Vms1 translocation to mitochondriaMol. Cell68(4)673-685(2017) 2.Kuria, K.A.M., Chepkwony, H., Govaerts, C., et al.The antiplasmodial activity of isolates from Ajuga remotaJ. Nat. Prod.65(5)789-793(2002) 3.Russo, A., Cardile, V., Piovano, M., et al.Pro-apoptotic activity of ergosterol peroxide and (22E)-ergosta-7,22-dien-5α-hydroxy-3,6-dione in human prostate cancer cellsChem. Biol. Interact.184(3)352-358(2010) 4.Kobori, M., Yoshida, M., Ohnishi-Kameyama, M., et al.Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cellsBr. J. Pharmacol.150(2)209-219(2007) 5.Yasukawa, K., Aoki, T., Takido, M., et al.Inhibitory effects of ergosterol isolated from the edible mushroom Hypsizigus marmoreus on TPA‐induced inflammatory ear oedema and tumour promotion in micePhytother. Res.8(1)10-13(1994) 6.Nam, K.S., Jo, Y.S., Kim, Y.H., et al.Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipesLife Sci.69(2)229-237(2001)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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