產(chǎn)品目錄

規(guī)格	2.5 mg
CAS	1190021-70-5
別名	N/A
化學(xué)名	N/A
分子式	C8H8D4N5O4P
分子量	277.2
溶解度	DMSO: soluble
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Adefovir-d4 is intended for use as an internal standard for the quantification of adefovir by GC- or LC-MS. Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil .1 Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2).2 It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 (EC50 = 7 μg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 μg/ml, respectively, in CEM cells), and varicella zoster virus (VZV; EC50 = 10 μg/ml in human embryonic lung fibroblasts).3 Adefovir (50 mg/kg, p.o.) reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with the retroviral complex LP-BM5.4 It also inhibits tumor growth induced by Moloney sarcoma virus (MSV) infection in mice at the same dose.5

1.Arimilli, M.N., Dougherty, J.P., Cundy, K.C., et al.Orally bioavailable acyclic nucleoside phosphonate prodrugs: Adefovir dipivoxil and bis(POC)PMPAAdvances in Antiviral Drug Design369-91(1999) 2.Laizure, S.C., Herring, V., Hu, Z., et al.The role of human carboxylesterases in drug metabolism: Have we overlooked their importance?Pharmacotherapy33(2)210-222(2013) 3.HolY, A., Votruba, I., Masojídková, M., et al.6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activityJ. Med. Chem.45(9)1918-1929(2002) 4.Rossi, L., Dominici, S., Serafini, S., et al.Pharmacokinetic and antiretroviral activity in mice of oral [P1,P2-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenineJ. Antimicrob. Chemother.50(3)365-374(2002) 5.Naesens, L., Balzarini, J., Bischofberger, N., et al.Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenineAntimicrob. Agents Chemother.40(1)22-28(1996)

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1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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