產(chǎn)品目錄

規(guī)格	1mg 5mg
CAS	102042-09-1
別名
化學(xué)名	(1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-22-ethyl-3',4',5',6'-tetrahydro-7,11,14,15,23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27
分子式	C45H74O12
分子量	807.1
溶解度	DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

21-hydroxy Oligomycin A is an antibiotic which was first isolated from S. cyaneogriseus ssp.noncyanogenus [1]. 21-hydroxy Oligomycin A functions as μM inhibitor of the multidrug efflux pump P-gp, and low nM inhibitors of K-Ras PM localization [1].

Cancer cell viability screening confirmed that 21-hydroxy Oligomycin A was cytotoxic to human colorectal carcinoma cells (IC50 > 3 μM), and was inhibitor of the ABC transporter efflux pump P-glyco-protein (P-gp). Significantly, 21-hydroxy Oligomycin A was exceptionally potent inhibitor of K-Ras PM localisation with Emax of 0.67–0.75 and an IC50 of 1.5–14 nM [1]. 21-hydroxy Oligomycin A was inhibitor of K-Ras PM localisation in MDCK cell with an IC50 of 4.82 ± 0.70 nM. 21-hydroxy Oligomycin A was moderately cytotoxic towards both SW620 and SW620 Ad300 cells with the IC50 of 14.4 ± 0.6 and 11.8 ± 3.1 μM, respectively. In the flow cytometry assay, 21-hydroxy Oligomycin A (20 μM) increased intracellular calcein fluorescence significantly when compared with the negative control [1].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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