產(chǎn)品目錄

規(guī)格	1mg
CAS	25514-31-2
別名
化學名	(1R,2S,3S,3aS,3a1R,4R,6aR,7aR,11aS,11bR)-methyl 1,2,9-trihydroxy-8,11a-dimethyl-4-((3-methylbutanoyl)oxy)-5,10-dioxo-2,3,3a,4,5,6a,7,7a,10,11,11a,11b-dodecahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-3-carboxylate
分子式	C26H34O11
分子量	522.54
溶解度	Soluble in DMSO
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

IC50: 7.7 nM against the parasites

Canine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, Babesia gibsoni and B. canis. Clinical signs of B. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. Bruceine A, a natural quassinoid compound extracted from the Brucea javanica (L.) Merr. dried fruits, was reported to have antibabesial activity.

In vitro: Bruceine A inhibited the in-vitro Babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM [1].

In vivo: Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. An untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. However, the two bruceine A-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].

Clinical trials: Currenlty there is no clinical data available.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術有限公司

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