產(chǎn)品目錄

規(guī)格	5mg 10mg 25mg 50mg
CAS	1211443-80-9
別名
化學(xué)名	(E)-7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)imino)-3,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
分子式	C23H31ClN8O
分子量	471
溶解度	Soluble in DMSO
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10,000 nM). Treatment with Ribociclib significantly inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, considering sensitive lines only, where sensitivity is defined as an IC50 of less than 1 μM. Ribociclib treatment of two neuroblastoma cell lines (BE2C and IMR5) with demonstrated sensitivity to CDK4/6 inhibition results in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. This G0/G1 arrest becomes significant at Ribociclib concentrations of 100 nM (p=0.007) and 250 nM (p=0.01), respectively[2].

CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (LEE011; 200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment[2].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

在線(xiàn)咨詢(xún)

留言注意事項(xiàng)：

1.遵守中華人民共和國(guó)有關(guān)法律、法規(guī)，尊重網(wǎng)上道德，承擔(dān)一切因您的行為而直接或間接引起的法律責(zé)任。

2.請(qǐng)您真實(shí)的反映產(chǎn)品的情況,不要捏造、誣蔑、造謠。如對(duì)產(chǎn)品有任何疑問(wèn),也可以留言咨詢(xún)。

3.未經(jīng)本站同意，任何人不得利用本留言簿發(fā)布個(gè)人或團(tuán)體的具有廣告性質(zhì)的信息或類(lèi)似言論。

您感興趣的產(chǎn)品*
您的單位*
聯(lián)系人*
聯(lián)系電話(huà)*
詳細(xì)地址*
常用郵箱*
請(qǐng)輸入您對(duì)我們的意見(jiàn)或建議*
驗(yàn)證碼*

同類(lèi)產(chǎn)品

CC-115 hydrochloride Hygromycin B (hydrate) Herboxidiene Bz-rA Phosphoramidite 5’-O-TBDMS-dG 1,4-Benzoquinone Heliquinomycin FD-211 Bottromycin A2 Guanosine 5’-diphosphate (sodium salt hydrate)

訂購(gòu)流程

訂貨流程

產(chǎn)品訂購(gòu)說(shuō)明:

1、報(bào)價(jià)含普票、運(yùn)費(fèi)。

2、常用試劑備貨充足，除對(duì)溫度要求極其嚴(yán)格的產(chǎn)品當(dāng)天可發(fā)貨。

3、進(jìn)口原裝產(chǎn)品要3-6周的貨期，詳細(xì)情況請(qǐng)咨詢(xún)客服。

4、訂貨時(shí)間為工作日每周一至周五16:00之前。

5、如需代為檢測(cè)，標(biāo)本對(duì)環(huán)境溫度高，可聯(lián)系客服安排專(zhuān)人取樣（限省內(nèi)客戶(hù)）。

6、代測(cè)免收代測(cè)費(fèi)，一周出結(jié)果。

7、產(chǎn)品因運(yùn)輸途中包裝破損請(qǐng)拒絕簽收，做退回。我們將在24小時(shí)之內(nèi)為您補(bǔ)發(fā) 損壞產(chǎn)品。

8、如因單位財(cái)務(wù)制度原因，可申請(qǐng)先發(fā)貨，報(bào)賬后付款（此條款僅限醫(yī)院、學(xué)校信譽(yù)良好客戶(hù)）。

付款方式

普票匯款信息

賬戶(hù) 名：上海生物

開(kāi) 戶(hù) 行：中國(guó)銀行山東省分行營(yíng)業(yè)部

賬號(hào)：2169 2341 6278

為方便廣大客戶(hù)辦理貨款我公司提供多個(gè)銀行的賬戶(hù)，學(xué)校、醫(yī)院客戶(hù)購(gòu)買(mǎi)產(chǎn)品如因單位財(cái)務(wù)制度原因可先發(fā)貨待報(bào)賬后匯款，請(qǐng)及時(shí)告知銷(xiāo)售人員已做具體操作。