產(chǎn)品目錄

規(guī)格	5 mg 10 mg 20 mg
CAS	17676-33-4
別名	25(27)-Dehydroruscogenin
化學(xué)名	spirosta-5,25(27)-diene-1β,3β-diol
分子式	C27H40O4
分子量	428.6
溶解度	≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
儲(chǔ)存條件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα [1]. Neoruscogenin is a natural sapogenin extracted from Butcher’s broom (Rusci rhizoma, Ruscus aculeatus, Ruscaceae) [2].

RAR-related orphan receptor alpha (RORα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. Genetic studies have revealed that RORα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3].

In vitro: In confluent human microvascular endothelial cells (HMEC-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μM (71.8%). The EC50 of neoruscogenin against the nuclear receptor RORα was 110 nM [1].

In vivo: In mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several RORα-inducible genes in the liver [1].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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