產品目錄

規(guī)格	1 mg
CAS	1189953-78-3
別名	N/A
化學名	N/A
分子式	C22H17D6N3O4.HCl
分子量	435.9
溶解度	DMSO: slightly, heated,Methanol: slightly soluble
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產品描述：

Erlotinib-d6 (hydrochloride) contains six deuterium atoms located on the methoxy group. It is intended for use as an internal standard for the quantification of erlotinib by GC- or LC-MS. Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 μM).1,2 This inhibits tumor growth in human head and neck carcinoma (HN5) tumor xenografts in mice with an ED50 value of 9 mg/kg.1 Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC50 = 4.6 μM) and JAK2 mutant JAK2V617F (IC50 = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia.3,4 Formulations containing erlotinib are used to treat certain forms of cancer, including non-small cell lung cancer.5,6

1.Ciardiello, F., and Tortora, G.A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptorClin. Cancer Res.7(10)2958-2970(2001) 2.Greulich, H., Chen, T.H., Feng, W., et al.Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutantsPLoS Med.2(11)(2005) 3.Yamasaki, F., Zhang, D., Bartholomeusz, C., et al.Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activityMol. Cancer Ther.6(8)2168-2177(2007) 4.Li, Z., Xu, M., Xing, S., et al.Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growthJ. Biol. Chem.282(6)3428-3432(2007) 5.Herbst, R.S., and Bunn, P.A., Jr.Targeting the epidermal growth factor receptor in non-small cell lung cancerClin. Cancer Res.9(16)5813-5824(2003) 6.Gerber, D.E.EGFR inhibition in the treatment of non-small cell lung cancerDrug Dev. Res.69(6)359-372(2008)

特別提醒：

1. 本產品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術有限公司