產(chǎn)品目錄

規(guī)格	1mg 5mg 10mg 50mg
CAS	215303-72-3
別名	JNJ-3026582
化學(xué)名	4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol
分子式	C27H24FN3O
分子量	425.5
溶解度	≤10mg/ml in ethanol;5mg/ml in DMSO;2mg/ml in dimethyl formamide
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

IC50: 1 and 11 μM for p38α and p38β, respectively

RWJ 67657 is an orally active inhibitor of the MAP kinases p38α and p38β.

Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by activated monocytes/macrophages and T lymphocytes, is implicated in several disease states, such as inflammatory bowel disease, rheumatoid arthritis, septic shock, as well as osteoporosis. The monocyte/macrophage production of TNF-alpha is dependent on the mitogen-activated protein kinase p38.

In vitro: RWJ 67657 could inhibit the release of TNF-alpha by lipopolysaccharide-treated human peripheral blood mononuclear cells, as well as the release of TNF-alpha from peripheral blood mononuclear cells treated with the superantigen staphylococcal enterotoxin B. RWJ 67657 was about 10-fold more potent than the literature standard p38 kinase inhibitor SB 203580 in all tested p38 dependent in-vitro systems tested. Moreover, RWJ 67657 was able to inhibit the enzymatic activity of recombinant p38alpha and beta, but not gamma or delta, and showed no significant activity against various other enzymes. In contrast, SB 203580 could significantly inhibit the tyrosine kinases p56 lck and c-src. In addition, RWJ 67657 did not inhibit T cell production of interleukin-2 or interferon-gamma and did not inhibit T cell proliferation in

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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