產(chǎn)品目錄

規(guī)格	1 mg 5 mg 10 mg 25 mg
CAS	2457232-14-1
別名	N/A
化學(xué)名	N/A
分子式	C14H12N4OS
分子量	284.3
溶解度	DMF: 15 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 10 mg/ml,Ethanol: insioluble,PBS (pH 7.2): insioluble
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

G6PDi-1 is a reversible and noncompetitive inhibitor of glucose-6-phosphate dehydrogenase (G6PDH; IC50 = 0.07 μM), the enzyme that converts G6P to 6-phosphogluconolactone using NADP+ as a cofactor in the first step of the pentose phosphate pathway.1 G6PDi-1 (10 and 50 μM) reduces NADPH levels in a variety of cultured cells, including red blood cells and T cells. It decreases colony formation of HCT116 cells when used at concentrations of 20 and 30 μM, an effect that can be rescued by the antioxidant N-acetyl cysteine. G6PDi-1 decreases the production of cytokines induced by phorbol 12-myristate 13-acetate and ionomycin in T cells and prevents PMA-induced oxidative burst in neutrophils.

1.Ghergurovich, J.M., García-Ca?averas, J.C., Wang, J., et al.A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathwayNat. Chem. Biol.16(7)731-739(2020)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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