產(chǎn)品目錄

規(guī)格	10mM (in 1mL DMSO)5mg 25mg 50mg 100mg
CAS	1300031-52-0
別名
化學(xué)名
分子式	C25H23ClN2O3
分子量	434.91
溶解度	≥ 17.7mg/mL in DMSO
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

GSK1324726A is a selective small molecule inhibitor of BET proteins with IC50 values of 41nM, 31nM and 22nM, respectively for BRD2, BRD3 and BRD4 [1].

GSK1324726A competes with histone H4 peptides for binding to the bromodomains of the BET proteins. It notably inhibits cell growth in neuroblastoma cell lines with a median GI50 value of 75nM. And it is also found to cause some level of net cell death. The mechanism of this is that GSK1324726A induces cytotoxicity in these cell lines. Treatment of GSK1324726A results in an induction of G1 arrest in SK–N-AS, SK–N–SH and CHP-212 cell lines. Meanwhile, caspase 3/7 induction is observed in SK–N–SH and CHP-212 cell lines. In mice bearing the neuroblastoma xenografts, GSK1324726A also shows the potency of inhibiting tumor growth [1].

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1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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