產(chǎn)品目錄

規(guī)格	10mg 50mg
CAS	796-42-9
別名
化學(xué)名	(E)-N'-((2-hydroxynaphthalen-1-yl)methylene)isonicotinohydrazide
分子式	C17H13N3O2
分子量	291.3
溶解度	≥ 29.1mg/mL in DMSO
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

AS8351 is a histone demethylase inhibitor.

Histone methylation is considered as a more dynamic modification with the discovery of Histone demethylases. Removal of methyl groups is mediated by LSD1, PAD14 and JmjC domain containing proteins.

In vitro: In a previous study, in order to identify indispensable factors for human fibroblasts, the authors removed combined compounds one by one and treated cells with the remaining compounds. Results showed that the number of beating clusters was significantly reduced by removal of seven compounds including AS8351. Moreover, these seven compounds inlcuding AS8351 were sufficient and necessary to induce cardiac reprogramming efficiently. The authors then investigated the role of the reprogramming compound of AS8351 and the results showed that AS8351 and its functional analogs could affect epigenetic modifications by competing with α- ketoglutarate for chelating iron/Fe(II) in some epigenetic enzymes, including the JmjC-domain-containing histone demethylases that require α-KG and iron as co-factors. In addition, the authors abrogated each of the 22 genes in the JmjC-KDM family by small hairpin RNAs and found that only with KDM5B knockdown, or using a KDM5B inhibitor, PBIT could phenocopy AS8351 in generating ciCMs, indicating that it might be a target of AS8351 [1].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: Up to now, AS8351 is still in the preclinical development stage.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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