產(chǎn)品目錄

規(guī)格	5mg 10mg 50mg 100mg 200mg 500mg
CAS	1092939-17-7
別名	INCB018424 phosphate;INCB 018424 phosphate;INCB-018424 phosphate;Ruxolitinib
化學(xué)名	(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric acid
分子式	C17H21N6O4P
分子量	404.36
溶解度	≥ 20.2 mg/mL in DMSO, ≥ 6.92 mg/mL in EtOH with ultrasonic and warming, ≥ 8.03 mg/mL in H2O with ultrasonic and warming
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.

Ruxolitinib (INCB018424) potently and selectively inhibits JAK2V617F-mediated signaling and proliferation. Ruxolitinib inhibits the growth of HEL cells with EC50 of 186 nM. Ruxolitinib markedly increases apoptosis in Ba/F3-EpoR-JAK2V617F cell system, and inhibits hematopoietic progenitor cell proliferation in primary MPN patient samples[1].

Ruxolitinib (180 mg/kg, p.o.) reduces the tumor burden of mice inoculated with JAK2V617F-expressing cells without causing anemia or lymphopenia[1].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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