產(chǎn)品目錄

規(guī)格	1 mg 5 mg
CAS	1246818-83-6
別名	N/A
化學(xué)名	N/A
分子式	C16H13ClD9N3O
分子量	316.9
溶解度	Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi.1 It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively.2 It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 μM) and is cytotoxic (EC20 = 38.9 μM) in an MDA-kb2 assay.3 Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses.4 It has a feminizing effect on male pups and a virilizing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning the platform location in the Morris water maze.5

1.Reinecke, P., Kaspers, H., Scheinpflug, H., et al.BAY HWG 1608, a new fungicide for foliar spray and seed-treatment use against a wide spectrum of fungal pathogensBr. Crop Prot. Conf.--Pests Dis., Proc. 141-46(1986) 2.Zarn, J.A., Brüschweiler, B.J., and Schlatter, J.R.Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 α-demethylase and aromataseEnviron. Health Perspect.111(3)255-261(2003) 3.Orton, F., Rosivatz, E., Scholze, M., et al.Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogensEnviron. Health Perspect.119(6)794-800(2011) 4.Taxvig, C., Hass, U., Axelstad, M., et al.Endocrine-disrupting activities in vivo of the fungicides tebuconazole and epoxiconazoleToxicol. Sci.100(2)464-473(2007) 5.Moser, V.C., Barone, S., Jr., Smialowicz, R.J., et al.The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in ratsToxicol. Sci.62(2)339-352(2001)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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賬戶(hù) 名：上海生物

開(kāi) 戶(hù) 行：中國(guó)銀行山東省分行營(yíng)業(yè)部

賬號(hào)：2169 2341 6278

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