產(chǎn)品目錄

規(guī)格	1 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C20H21D3O6
分子量	363.4
溶解度	DMSO: slightly soluble,Methanol: slightly, heated
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Triptolide-d3 is intended for use as an internal standard for the quantification of triptolide by GC- or LC-MS. Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities.1,2,3,4 It inhibits dCTP pyrophosphatase 1 (Ki = 168 μM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis.1 It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human non-small cell lung cancer (NSCLC) cells when used at a concentration of 50 nM.2 Intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer. Triptolide (0.2 mg/kg) reduces intestinal inflammation and prevents colon shortening in a mouse model of ulcerative colitis induced by dextran sulfate .3 It also inhibits skin allograft rejection and increases graft survival time in mice when administered at a dose of 0.1 mg/kg per day post-transplantation.4

1.Corson, T.W., Cavga, H., Aberle, N., et al.Triptolide directly inhibits dCTP pyrophosphataseChemBioChem12(11)1767-1773(2011) 2.Song, J.M., Molla, K., Anandharaj, A., et al.Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signalingOncotarget.8(16)26927-26940(2017) 3.Tang, B., Zhu, J., Zhang, B., et al.Therapeutic potential of triptolide as an anti-inflammatory agent in dextran sulfate sodium-induced murine experimental colitisFront. Immunol.11592084(2020) 4.Yang, S.-X., Gao, H.-L., Xie, S.-S., et al.Immunosuppression of triptolide and its effect on skin allograft survivalInt. J. Immunopharmacol.14(6)963-969(1992)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請(qǐng)穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

在線咨詢

留言注意事項(xiàng)：

1.遵守中華人民共和國(guó)有關(guān)法律、法規(guī)，尊重網(wǎng)上道德，承擔(dān)一切因您的行為而直接或間接引起的法律責(zé)任。

2.請(qǐng)您真實(shí)的反映產(chǎn)品的情況,不要捏造、誣蔑、造謠。如對(duì)產(chǎn)品有任何疑問,也可以留言咨詢。

3.未經(jīng)本站同意，任何人不得利用本留言簿發(fā)布個(gè)人或團(tuán)體的具有廣告性質(zhì)的信息或類似言論。

您感興趣的產(chǎn)品*
您的單位*
聯(lián)系人*
聯(lián)系電話*
詳細(xì)地址*
常用郵箱*
請(qǐng)輸入您對(duì)我們的意見或建議*
驗(yàn)證碼*