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  • 3004967995

Actinomycin D

  • 產(chǎn)品貨號(hào)：CS-01Y65167
  • 產(chǎn)品價(jià)格：電議
  • 產(chǎn)品產(chǎn)地：進(jìn)口、國(guó)產(chǎn)
  • 包裝類(lèi)型:10mM (in 1mL DMSO) 5mg 10mg 50mg 500mg 1g
  • 采購(gòu)熱度：242
  • 庫(kù)存：100
  • CAS號(hào)：50-76-0
  • 方法：
  • 含量：>98.00%
  • 品牌名稱(chēng):莼試
  • 分子式：C62H86N12O16
  • 分子量：1255.43

簡(jiǎn)介內(nèi)容：質(zhì)量保證、價(jià)格優(yōu)惠

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標(biāo)簽:Actinomycin D 

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商品詳情購(gòu)物流程代測(cè)服務(wù)付款方式常見(jiàn)問(wèn)題

化學(xué)性質(zhì)：                                                                                                             

規(guī)格

10mM (in 1mL DMSO) 5mg 10mg 50mg 500mg 1g

CAS

50-76-0

別名

DACTINOMYCIN

化學(xué)名

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide

分子式

C62H86N12O16

分子量

1255.43

溶解度

≥ 62.75 mg/mL in DMSO

儲(chǔ)存條件

Store at -20℃; protected from light

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

產(chǎn)品描述：                                                                                                             

IC50: Actinomycin D showed a concentration-dependent decrease of DNA repair activity with the IC50 of 0.42 μM [1].

Actinomycin D (dactinomycin), a member of actinomycines, which are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces. Have been used for many years as an older chemotherapy, actinomycin D binds to double- and single-stranded DNA to inhibit DNA and RNA synthesis by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.

In vitro: A previous study was designed to determine the effects of actinomycin D on leptin release by isolated rat adipocytes during primary culture for 24 hr. Results showed that both actinomycin D and dexamethasone reduced the loss of leptin mRNA seen over the 24-hr incubation. Maximal effects on leptin release and leptin mRNA accumulation required only 0.1 μM of actinomycin D, a concentration that had no significant effect on the 18S RNA content of adipocytes at the end of a 24-hr incubation. In contrast to the reduced loss of leptin mRNA seen at 24 hr, the loss of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid (GAPDH mRNA) was enhanced in the presence of 0.1 μM of actinomycin D. These results demonstrated a unique regulation of leptin release and leptin mRNA levels by actinomycin D [2].

In vivo: A rat in vivo study showed that the effect of actinomycin D on the time course of the population spike potentiation was more pronounced than the effect on the time course of the EPSP component, suggesting different mechanisms for the two forms of potentiation. Moreover, both intrahippocampal and intracerebroventricular injection of actinomycin D prevented a late stage of LTP in the dentate gyrus in vivo measured as the population spike amplitude [3].

Clinical trial: Actinomycin is intravenously administered and most commonly used in the treatment of a variety of cancers, including gestational trophoblastic neoplasia, wilms' tumor, rhabdomyosarcoma, ewing's sarcoma and malignant hydatidiform mole. Combined with other drugs in chemotherapy regimens, such as the VAC regimen, it will be used for treating rhabdomyosarcoma and Ewing's Sarcoma. In addition, it is also used as a radiosensitizer in adjunct to radiotherapies, as it increases the tumor cells radiosensitivity.

Reference:

[1] Barret JM, Salles B, Provot C, Hill BT. Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplate assay. Carcinogenesis. 1997 ;18(12):2441-5.

[2] Fain JN, Bahouth SW. Stimulation of leptin release by actinomycin D in rat adipocytes. Biochem Pharmacol. 1998;55(8):1309-14.

[3] Frey U, Frey S, Schollmeier F, Krug M. Influence of actinomycin D, a RNA synthesis inhibitor, on long-term potentiation in rat hippocampal neurons in vivo and in vitro. J Physiol. 1996;490(Pt 3):703-11.

 

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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