產(chǎn)品目錄

規(guī)格	1mg 5mg 10mg 25mg
CAS	521-49-3
別名	N/A
化學名	2,3-dihydro-2,3,3-trimethyl-naphtho[1,2-b]furan-4,5-dione
分子式	C15H14O3
分子量	242.3
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

(±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities.[1][2][3][4] It exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L)[1]. (±)-Dunnione also reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM)[2]. It is a substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) that increases production of reactive oxygen species (ROS) and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM).[3] (±)-Dunnione (20 mg/kg per day for 4 days) increases intracellular NAD+ and prevents inflammatory cytokine production and small intestinal damage induced by cisplatin in mice.[4]

Reference:

[1]. Khambay, B.P.S., Batty, D., Jewess, P.J., et al. Mode of action and pesticidal activity of the natural product dunnione and of some analogues Pest. Manag. Sci. 59(2), 174-182 (2003).

[2]. Salas, C.O., Faúndez, M., Morello, A., et al. Natural and synthetic naphthoquinones active against Trypanosoma cruzi: An initial step towards new drugs for Chagas disease Curr. Med. Chem. 18(1), 144-161 (2011).

[3]. Bian, J., Xu, L., Deng, B., et al. Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1) Bioorg. Med. Chem. Lett. 25(6), 1244-1248 (2015).

[4]. Pandit, A., Kim, H.-J., Oh, G.-S., et al. Dunnione ameliorates cisplatin-induced small intestinal damage by modulating NAD(+) metabolism Biochem. Bioph. Res. Commun. 467(4), 697-703 (2015).

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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