產(chǎn)品目錄

規(guī)格	10mM (in 1mL DMSO) 20mg
CAS	31721-94-5
別名
化學(xué)名	5,7-dihydroxychromen-4-one
分子式	C9H6O4
分子量	178.14
溶解度	≥ 7.05mg/mL in DMSO
儲存條件
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

5,7-Dihydroxychromone is a natural antioxidant extracted from plants, such as peanut shell. It acts as an Nrf2/ARE signal activator [1]; or a PPARγ agonist [2].

NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) signal has an important effect on the induction of antioxidant gene expression, the activation of Nrf2 can neutralize oxidative stress. Under normal state, Nrf2 is localized in the cytoplasm, antioxidant agents induce nuclear translocation of Nrf2 and subsequently make the Nrf2/ARE complex mediate the induction of antioxidant enzyme genes.

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family;

PPAR isoforms (α, β/δ, and γ) are key regulators of glucose absorption, lipid metabolism, proliferation, and cellular differentiation. PPARγ agonists are commonly used as insulin sensitizers for the treatment of type 2 diabetes mellitus.

In vitro: 5,7-Dihydroxychromone (DHC) (0.4–10 μM) was found to protect against neuronal cell death and the ROS generation in a dose-dependent manner in 6-OHDA-induced SH-SY5Y cells. DHC (0.08–10 μM) also dose-dependently increased the induction of nuclear Nrf2, which has a binding affinity to ARE and activates ARE-driven phase II antioxidant enzymes; NQO1, HO-1, and GCLc[1]. Daphniphyllum macropodum fruit extract (DME) administration in vivo and its major component 5,7-dihydroxychromone (1, 5, and 10 μg/mL) treatment in vitro dose dependently increased the mRNA expressions of PPARγ and LXRα in 3T3-L1 cells, 5,7-dihydroxychromone (1 μg/mL ) also potently increased adipocyte differentiation, suggesting that it functions as a PPARγ agonist and has anti-diabetic properties[2]. 5,7-dihydroxychromone also demonstrated significant activity against HIV replication in H9 lymphocyte cells[3].

References:

[1]. Kim D W, Lee K, Kwon J, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5, 7-Dihydroxychromone: Activation of the Nrf2/ARE pathway[J]. Life sciences, 2015, 130: 25-30.

[2]. Koo H J, Kwak J H, Kang S C. Anti-diabetic properties of Daphniphyllum macropodum fruit and its active compound[J]. Bioscience, biotechnology, and biochemistry, 2014, 78(8): 1392-1401.

[3]. Wu P L, Lin F W, Wu T S, et al. Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis[J]. Chemical and pharmaceutical bulletin, 2004, 52(3): 345-349.

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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