產(chǎn)品目錄

規(guī)格	20mg
CAS	480-10-4
別名
化學(xué)名	5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
分子式	C21H20O11
分子量	448.38
溶解度	≥ 44.8mg/mL in DMSO
儲存條件
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Astragalin is an inhibitor of eotaxin-1, PKCβ2 phosphorylation, activation of NF-κB/MAPK and PLCγ1 that correlated with oxidase in a dose dependent manner [1] [2].

Oxidative stress means disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell. And it is reported that oxidative stress can cause disruptions in normal mechanisms of cellular signaling, such as cancer development, Parkinson's disease, Alzheimer's disease, atherosclerosis, passive cutaneous reactions, inflammation, heart failure, myocardial infarction, Sickle Cell Disease, infection, and chronic fatigue syndrome [1, 3]. In human osteoaithritis chondrocyte cells, astragalin inhibited the activation of NF-κB and MAPK [2].

Astragalin is reported to have the ability of anti-oxidant effect. When tested with human basophilic cell line KU812, oral administration of astragalin inhibited the release of histamine and passive cutaneous reactions [4]. In airway epithelial BEAS-2B cells, astragalin treatment antagonized endotoxin-induced oxidative stress that is responsible to airway dysfunction and inflammation [1]. When tested with human red blood cells induced in the oxidative state, administration of astragalin suppressed the [3].

In mouse model with NC/Nga atopic dermatitis, astragalin treatment significantly suppressed the dermatitis development, scratching behavior and serum IgE elevation [4].

References:

[1]. Cho, I.H., et al., Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling. BMC Pulm Med, 2014. 14: p. 122.

[2]. Ma, Z., et al., Astragalin inhibits IL-1beta-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-kappaB and MAPK activation. Int Immunopharmacol, 2015. 25(1): p. 83-87.

[3]. Choi, J., et al., Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells. Arch Pharm Res, 2013. 36(7): p. 912-7.

[4]. Kotani, M., et al., Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J Allergy Clin Immunol, 2000. 106(1 Pt 1): p. 159-66.

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實(shí)驗(yàn)服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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