產(chǎn)品目錄

規(guī)格	500μg 2.5mg
CAS	38620-77-8
別名	N/A
化學(xué)名	4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-hexyl-17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,23E,25E-pentaen-2-one
分子式	C35H58O10
分子量	638.8
溶解度	Soluble in DMSO, DMF, Ethanol, Methanol
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]

Reference:

[1]. Bergy, M.E., and Eble, T.E. The filipin complex. Biochemistry 7(2), 653-659 (1968).

[2]. Balcavage, W.X., Beale, M., Chasen, B., et al. Effect of filipin on rat-liver and yeast mitochondria. Biochim. Biophys. Acta. 162(4), 525-532 (1968).

[3]. Sessa, G., and Weissmann, G. Effects of four components of the polyene antibiotic, filipin, on phospholipid spherules (liposomes) and erythrocytes. J. Biol. Chem. 243(16), 4364-4371 (1968).

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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