產(chǎn)品目錄

規(guī)格	250 μg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	[13C]13H14N2O4S2
分子量	339.3
溶解度	Acetonitrile: 3 mg/ml
儲存條件	Store at-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Gliotoxin-13C13 is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi with diverse biological activities.1,2,3,4,5,6,7,8 It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3 Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5 It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).6 Under reducing conditions, gliotoxin inhibits leukotriene A4 hydrolase epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4 synthesis in neutrophils and monocytes.7 In vivo, gliotoxin (5 mg/kg) reduces LTB4 plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of peritonitis induced by zymosan A . It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 μM, respectively).8

1.Kwon-Chung, K.J., and Sugui, J.A.What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus?Med. Mycol.47(Suppl 1)S97-S103(2009) 2.Kroll, M., Arenzana-Seisdedos, F., Bachelerie, F., et al.The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasomeChem. Biol.6(10)689-698(1999) 3.Pahl, H.L., Krauss, B., Schulze-Osthoff, K., et al.The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-κBJ. Exp. Med.183(4)1829-1840(1996) 4.Anselmi, K., Stolz, D.B., Nalesnik, M., et al.Gliotoxin causes apoptosis and necrosis of rat Kupffer cells in vitro and in vivo in the absence of oxidative stress: Exacerbation by caspase and serine protease inhibitionJ. Hepatol.47(1)103-113(2007) 5.Orciuolo, E., Stanzani, M., Canestraro, M., et al.Effects of Aspergillus fumigatus gliotoxin and methylprednisolone on human neutrophils: Implications for the pathogenesis of invasive aspergillosisJ. Leukoc. Biol.82(4)839-848(2007) 6.Aljofan, M., Sganga, M.L., Lo, M.K., et al.Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitroVirol. J.6187(2009) 7.K?nig, Pace, S., Pein, H., et al.Gliotoxin from Aspergillus fumigatus abrogates leukotriene B4 formation through inhibition of leukotriene A4 hydrolaseCell. Chem. Biol.26(4)524-534(2019) 8.Vigushin, D.M., Mirsaidi, N., Brooke, G., et al.Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivoMed. Oncol.21(1)21-30(2004)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

在線咨詢

留言注意事項：

1.遵守中華人民共和國有關(guān)法律、法規(guī)，尊重網(wǎng)上道德，承擔(dān)一切因您的行為而直接或間接引起的法律責(zé)任。

2.請您真實的反映產(chǎn)品的情況,不要捏造、誣蔑、造謠。如對產(chǎn)品有任何疑問,也可以留言咨詢。

3.未經(jīng)本站同意，任何人不得利用本留言簿發(fā)布個人或團(tuán)體的具有廣告性質(zhì)的信息或類似言論。

您感興趣的產(chǎn)品*
您的單位*
聯(lián)系人*
聯(lián)系電話*
詳細(xì)地址*
常用郵箱*
請輸入您對我們的意見或建議*
驗證碼*