產(chǎn)品目錄

規(guī)格	1mg
CAS	2012598-75-1
別名	N/A
化學(xué)名	N/A
分子式	C22H22Cl2D8N10?2HCl
分子量	586.4
溶解度	DMSO: soluble,Methanol: soluble
儲(chǔ)存條件	Store at-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述

Chlorhexidine-d8 is intended for use as an internal standard for the quantification of chlorhexidine by GC- or LC-MS. Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent.1 It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml).2 It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively).3 Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml).4,5 It generates cations that bind to and destabilize the bacterial cell wall to induce death.6 Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.7 Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.

1.Karpiński, T.M., and Szkaradkiewicz, A.K.Chlorhexidine--Pharmaco-biological activity and applicationEur. Rev. Med. Pharmacol. Sci.19(7)1321-1326(2015) 2.McDanel, J.S., Murphy, C.R., Diekema, D.J., et al.Chlorhexidine and mupirocin susceptibilities of methicillin-resistant Staphylococcus aureus from colonized nursing home residentsAntimicrob. Agents Chemother.57(1)552-558(2013) 3.Clark, S.M., Loeffler, A., and Bond, R.Susceptibility in vitro of canine methicillin-resistant and -susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: Opportunities for topical therapy of canine superficial pyodermaJ. Antimicrob. Chemother.70(7)2048-2052(2015) 4.Bhardwaj, P., Hans, A., Ruikar, K., et al.Reduced chlorhexidine and daptomycin susceptibility in vancomycin-resistant enterococcus faecium after serial chlorhexidine exposureAntimicrob. Agents Chemother.62(1)e01235-01217(2017) 5.Scheibler, E., da Silva, R.M., Leite, C.E., et al.Stability and efficacy of combined nystatin and chlorhexidine against suspensions and biofilms of Candida albicansArch. Oral Biol.8970-76(2018) 6.Barrett-Bee, K., Newboult, L., and Edwards, S.The membrane destabilising action of the antibacterial agent chlorhexidineFEMS Microbiol. Lett.119(1-2)249-253(1994) 7.Gendron, R., Grenier, D., Sorsa, T., et al.Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by chlorhexidineClin. Diag. Lab. Immun.6(3)437-439(1999)

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1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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