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Enniatin B

  • 產(chǎn)品貨號(hào)：CS-01Y64433
  • 產(chǎn)品價(jià)格：電議
  • 產(chǎn)品產(chǎn)地：進(jìn)口、國(guó)產(chǎn)
  • 包裝類(lèi)型:1mg 5mg
  • 采購(gòu)熱度：176
  • 庫(kù)存：100
  • CAS號(hào)：917-13-5
  • 方法：
  • 含量：>98.00%
  • 品牌名稱(chēng):莼試
  • 分子式：C33H57N3O9
  • 分子量：639.8

簡(jiǎn)介內(nèi)容：質(zhì)量保證、價(jià)格優(yōu)惠

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標(biāo)簽:Enniatin B 

產(chǎn)品目錄

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商品詳情購(gòu)物流程代測(cè)服務(wù)付款方式常見(jiàn)問(wèn)題

化學(xué)性質(zhì)：                                                                                                             

規(guī)格

1mg 5mg

CAS

917-13-5

別名

Antibiotic 86/88

化學(xué)名

cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl

分子式

C33H57N3O9

分子量

639.8

溶解度

DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble

儲(chǔ)存條件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

產(chǎn)品描述：                                                                                                             

Enniatin B is an ionophore antibiotic.

Enniatins are one of the cyclohexadepsipeptides produced by various species of the genus Fusarium, and are reported to have antibiotic, ionophoric, and in-vitro hypolipidaemic activities.

In vitro: A non-toxic concentration of enniatin B could strongly inhibit a Pdr5p-mediated efflux of cycloheximide or cerulenin in Pdr5p-overexpressing cells. The mode of Pdr5p inhibition caused by enniatin B was competitive against FK506. However, enniatin B could not inhibit the function of Snq2p, a homologue of Pdr5p [1]. Another study showed that enniatin B was a relatively poor ionophore that could facilitate import of K+ and Na+ across membranes [2]. It was also found that like other enniatins, enniatin B was able to inhibit acyl-CoA: cholesterol acyltransferase [3].

In vivo: After oral administration to mice, no toxicological signs or pathological changes were observed. Moreover, enniatin B was found in all tissues and serum but not in urine, and the highest amounts was measured in liver and fat. Three phase I metabolites of enniatin B were found in liver and colon, with dioxygenated-enniatin B being most prominent [4].

Clinical trial: Up to now, enniatin B is still in the preclinical development stage.

References:

[1] K.  Hiraga, S. Yamamoto, H. Fukuda, et al. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 328(4), 1119-1125 (2005).

[2] M.  R. Kamyar, P. Rawnduzi, C. R. Studenik, et al. Investigation of the electrophysiological properties of enniatins. Archives of Biochemistry and Biophysics429(2), 215-223 (2004).

[3] Tomoda, X.  H. Huang, J. Cao, et al. Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J.Antibiot.(Tokyo) 45(10),1626-1632 (1992).

[4] Rodríguez-Carrasco Y et al.  Mouse tissue distribution and persistence of the food-born fusariotoxins Enniatin B and Beauvericin. Toxicol Lett. 2016 Apr 15;247:35-44.

 

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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